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KMID : 1160420210030020107
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Epilia: Epilepsy Commun
2021 Volume.3 No. 2 p.107 ~ p.111
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Possible Effect of Perampanel on Epilepsia Partialis Continua after Generalized Tonic-Clonic Status Epilepticus
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Yang Tae-Won
Kim Do-Hyung
Kim Young-Soo
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Abstract
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Epilepsia partialis continua (EPC), defined as a syndrome of continuous focal motor seizures, is a rare form of status epilepticus. EPC is a difficult-to-treat condition that tends to be refractory. Perampanel (PER) is the most recently approved antiepileptic drug for focal and generalized epilepsy and has a distinct and selective mode of action on alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors. There are also anecdotal reports on its use in status epilepticus. Herein, we present a case where PER was the last antiepileptic drug introduced for the treatment of EPC before its termination 48 hours later. PER might be a safe choice that can be considered as an additional option for patients with EPC.
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KEYWORD
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Perampanel, Epilepsia partialis continua, Status epilepticus
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